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Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis

Identifieur interne : 000192 ( Main/Exploration ); précédent : 000191; suivant : 000193

Sentinel lymph node mapping in endometrial cancer: a systematic review and meta-analysis

Auteurs : Hefeng Lin [République populaire de Chine] ; Zheyuan Ding [République populaire de Chine] ; Vishnu Goutham Kota [République populaire de Chine] ; Xiaoming Zhang [République populaire de Chine] ; Jianwei Zhou [République populaire de Chine]

Source :

RBID : PMC:5542296

Abstract

Endometrial cancer is the most frequent tumor in the female reproductive system, while the sentinel lymph node (SLN) mapping for diagnostic efficacy of endometrial cancer is still controversial. This meta-analysis was conducted to evaluate the diagnostic value of SLN in the assessment of lymph nodal involvement in endometrial cancer. Forty-four studies including 2,236 cases were identified. The pooled overall detection rate was 83% (95% CI: 80–86%). The pooled sensitivity was 91% (95% CI: 87–95%). The bilateral pelvic node detection rate was 56% (95% CI: 48–64%). Use of indocyanine green (ICG) increased the overall detection rate to 93% (95% CI: 89–96%) and robotic-assisted surgery also increased the overall detection rate to 86% (95% CI: 79–93%). In summary, our meta-analysis provides strong evidence that sentinel node mapping is an accurate and feasible method that performs well diagnostically for the assessment of lymph nodal involvement in endometrial cancer. Cervical injection, robot-assisted surgery, as well as using ICG, optimized the sensitivity and detection rate of the technique. Sentinel lymph mapping may potentially leading to a greater utilization by gynecologic surgeons in the future.


Url:
DOI: 10.18632/oncotarget.16662
PubMed: 28410225
PubMed Central: 5542296


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<p>Endometrial cancer is the most frequent tumor in the female reproductive system, while the sentinel lymph node (SLN) mapping for diagnostic efficacy of endometrial cancer is still controversial. This meta-analysis was conducted to evaluate the diagnostic value of SLN in the assessment of lymph nodal involvement in endometrial cancer. Forty-four studies including 2,236 cases were identified. The pooled overall detection rate was 83% (95% CI: 80–86%). The pooled sensitivity was 91% (95% CI: 87–95%). The bilateral pelvic node detection rate was 56% (95% CI: 48–64%). Use of indocyanine green (ICG) increased the overall detection rate to 93% (95% CI: 89–96%) and robotic-assisted surgery also increased the overall detection rate to 86% (95% CI: 79–93%). In summary, our meta-analysis provides strong evidence that sentinel node mapping is an accurate and feasible method that performs well diagnostically for the assessment of lymph nodal involvement in endometrial cancer. Cervical injection, robot-assisted surgery, as well as using ICG, optimized the sensitivity and detection rate of the technique. Sentinel lymph mapping may potentially leading to a greater utilization by gynecologic surgeons in the future.</p>
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<li>Hangzhou</li>
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<li>Université de Zhejiang</li>
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<name sortKey="Zhang, Xiaoming" sort="Zhang, Xiaoming" uniqKey="Zhang X" first="Xiaoming" last="Zhang">Xiaoming Zhang</name>
<name sortKey="Zhou, Jianwei" sort="Zhou, Jianwei" uniqKey="Zhou J" first="Jianwei" last="Zhou">Jianwei Zhou</name>
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</record>

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